Cornered in a building, Lupin is given the shock of a lifetime; Zenigata has been pulled off the Lupin case permanently. A rather drunken Zenigata informs Lupin of the news personally and reveals that his new assignment is to track down a group of illegal arms dealers known as "Shot Shell". Lupin decides to steal Shot Shell's profits and is surprised to have Zenigata join forces with him.
ICPO has given a vicious ex-mercenary named Keith one mission – bring Lupin in dead or alive. With danger lurking in every corner of the map, Lupin decides to use a nuclear submarine as bait for his plans. Can Lupin find Shot Shell and relieve them of their financial burden before Keith relieves Lupin of his life? And what secret past does Karen, a beautiful Russian scientist, and Jigen share?